Interleukin-1β activates a short STAT-3 isoform in clonal insulin-secreting cells
Identifieur interne : 000B52 ( Main/Exploration ); précédent : 000B51; suivant : 000B53Interleukin-1β activates a short STAT-3 isoform in clonal insulin-secreting cells
Auteurs : Nicholas M. Morton [Royaume-Uni] ; Rolf P. De Groot [Pays-Bas] ; Michael A. Cawthorne [Royaume-Uni] ; Valur Emilsson [Royaume-Uni]Source :
- FEBS Letters [ 0014-5793 ] ; 1998.
Abstract
Interleukin-1β (IL-1β) is a potent inflammatory cytokine involved in type 1 diabetes and acts through defined IL-1β signaling pathways. In the present work we describe induction of DNA binding activity to signal transducer and activator of transcription (STAT) in response to IL-1β in clonal insulin-secreting cells. Moreover, IL-1β activates a short isoform of STAT-3 that potently stimulates transcription. Immunoprecipitation studies reveal an interaction between the activated STAT-3 and the IL-1 receptor accessory protein indicating an association between the two signaling pathways. This may be a novel point of transduction cross talk and an additional mechanism utilised by IL-1β in the pancreatic β-cell during the process of type 1 diabetes.
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DOI: 10.1016/S0014-5793(98)01623-8
Affiliations:
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Morton</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Clore Laboratory, The University of Buckingham, Hunter Street, Buckingham MK18 1EG</wicri:regionArea><wicri:noRegion>Buckingham MK18 1EG</wicri:noRegion></affiliation></author><author><name sortKey="De Groot, Rolf P" sort="De Groot, Rolf P" uniqKey="De Groot R" first="Rolf P." last="De Groot">Rolf P. De Groot</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Pulmonary Diseases, University Hospital Utrecht, P.O. Box 85500, 3508 GA Utrecht</wicri:regionArea><wicri:noRegion>3508 GA Utrecht</wicri:noRegion></affiliation></author><author><name sortKey="Cawthorne, Michael A" sort="Cawthorne, Michael A" uniqKey="Cawthorne M" first="Michael A." last="Cawthorne">Michael A. 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In the present work we describe induction of DNA binding activity to signal transducer and activator of transcription (STAT) in response to IL-1β in clonal insulin-secreting cells. Moreover, IL-1β activates a short isoform of STAT-3 that potently stimulates transcription. Immunoprecipitation studies reveal an interaction between the activated STAT-3 and the IL-1 receptor accessory protein indicating an association between the two signaling pathways. This may be a novel point of transduction cross talk and an additional mechanism utilised by IL-1β in the pancreatic β-cell during the process of type 1 diabetes.</div></front></TEI><affiliations><list><country><li>Pays-Bas</li><li>Royaume-Uni</li></country></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Morton, Nicholas M" sort="Morton, Nicholas M" uniqKey="Morton N" first="Nicholas M." last="Morton">Nicholas M. 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